Serendipity in Research Involving Laboratory Animals

Drugs Discovered through Serendipity in the Laboratory

The department of internal medicine at the University of Strassburg in the 1880s was noted for its investigations into intestinal worms. Adolf Kussmaul, the director, asked two young assistants, Arnold Cahn and Paul Hepp, to treat patients with naphthalene as it had been used elsewhere as an internal antiseptic. The young doctors were disappointed with the initial results, but Hepp persevered w...

Animals in the research laboratory: science or pseudoscience?

What distinguishes science from pseudoscience? Is the demarcation linked to the application of the laws of probability? Is it possible to derive any valid law of nature from a finite number of facts? Answers to such questions, and, thus, a construction of a line of demarcation between science and pseudoscience are problems of vital social and political importance. This issue is especially relev...

CIOMS International Guiding Principles for Biomedical Research Involving Animals.

Animal experimentation is fundamental to the biomedical sciences, not only for the advancement of man's understanding of the nature of life and the mechanisms of specific vital processes, but also for the improvement of methods of prevention, diagnosis, and treatment of disease both in man and in animals. The use of animals is also indispensable for testing the potency and safety of biological ...

Guiding principles for research involving animals and human beings.

THE AMERICAN PHYSIOLOGICAL SOCIETY (APS) endorses the Recommendations from the Declaration of Helsinki and the Guiding Principles in the Care and Use of Animals and insists that all investigations involving humans and all animal experimentation reported in its publications be conducted in conformity with these principles. Editors/Associate Editors are expected to refuse papers in which evidence...

Rethinking the ethics of research involving nonhuman animals: introduction.